紀要論文

心筋細胞における温度応答性の解析

ANALYSIS OF TEMPERATURE RESPONSIVENESS OF CARDIOMYOCYTES

jpn

24368083

https://doi.org/10.15002/00025413

法政大学大学院理工学研究科

法政大学大学院紀要. 理工学研究科編

63

1

2

2022-03-24

Version of Record

Cooling heart during the transplant and hypothermia therapy are provided, however, low temperature can cause arrythmia. Thus, the transition process of beating pattern during rapid or gradual temperature change should be revealed. In this study, we investigated Inter-Spike Interval (ISI) and Short-Term Variability of ISI (STV_ISI) within temperature change from 37 to 5℃ and from 5 to 37℃ by using Multi-Electrode Array (MEA) system. ISI, stabled at 37℃, increased to at 13℃ and disappeared. STV_ISI which is fluctuation of ISI also increased with temperature rise. Stopped beating at lower temperatures resumed at 26℃ and ISI decreased to at 37℃. STV_ISI decreased with temperature drop too, however, STV_ISI increased at around 30℃. More gradual temperature rise to 30℃ resulted in decreasing of STV_ISI at all temperatures. It is considered that gradual temperature change can inhibit arrythmia caused by temperature change.

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