紀要論文

重みづけスプライン平滑化を応用した２型糖尿病患者における心電図 RRI-QTI 日内リズム特徴分析

Weighted Spline Smoothing Technique Applied to the Circadian Trend Estimation for RR-QT Intervals of Type 2 Diabetic Patients

jpn

21879923

https://doi.org/10.15002/00010479

法政大学大学院理工学・工学研究科

55

1

5

2014-03-24

Version of Record

This paper describes a new method of trend estimation based on weighted spline smoothing technique. The method aims to cope with both smoothness and tracking capability at rapidly changing period of the data. Although QT intervals are extensively utilized for characterizingT2DM pathological conditions, their long term circadian changes are not fully studied. The cosinor method has been utilized in the preliminary work describing the relation between circadian QT interval changes and insulin resistance. This work proposes to utilize weighted spline smoothing technique for more precise characterization of the circadian variation of the QT interval sequences. Circadian changes of QT intervals for 19 T2DM patients and 24normal subjects are analyzed by the proposed method. The estimated trends yield new indices QTI Amplitude. Proposed method showed QTI Amplitude difference QT in intervals/day for T2DM patients and normal subjects are 0.12 ± 0.04 (ms) and 0.17 ± 0.05(ms) (p<0.001). QTI Amplitude of T2DM patients are significantly smaller than normal subjects. The circadian amplitude obtained by the standard cosinor method showed significant difference between two groups. However, the significance level is much higher with the new method.

Article

AA12677220