学位論文

スプライン平滑化を用いた糖尿病患者の日内変動検証

jpn

2013-03-24

Not Applicable (or Unknown)

2013-03-24

修士(工学)

工学研究科情報電子工学専攻; 指導教授: 八名和夫

This paper examines the characteristics of circadian change of diabetic patients. Recently their circadian changes are found to be associated with insulin resistance suggesting the importance of issue. The purpose of this study was to verify the presence or absence of diabetes patient-specefic rhythm of circadian change of QT interval, RR intervals and QTc. Previous studies have used the cosinor method to circadian change. In this paper, for better characterization of the circadian change, spline smoothing technique applied to a decimated data. New indices named circadian transition time (CT) and circadian transition amplitude (CA) associated with the subjects' awakening process are defined to characterize diabetic patients' condition.

Thesis