学位論文

アズレン誘導体と各種フッ素化剤との反応

REACTIONS OF AZULENE DERIVATIVES WITH VARIOUS FLUORINATING A GENTS

jpn

2005-03-24

Not Applicable (or Unknown)

2005-03-24

修士(工学)

工学研究科物質化学専攻; 指導教授: 中村暢男

Azulene derivative are used for pharmaceutical intermediates, because those have been found to posses mild anti-allergic and anti-ulcer activities. We focused attention to the fluorine atom. Organofluorine compounds have recieved much attention due to their unique physical/chemical properties that may give rise to useful biological activities or novel characteristics. In this research, we tried fluorination of azulene derivative by using various fluorinating agents. As a result, it succeeded in fluorination of the Azulene carboxylic acid derivatives by using 2,2-Difluoro-1,3-dimethylimidazolidine(DFI).

Thesis